NBI is a private, non-profit, pharmaceutical manufacturer of human plasma-derived medicinal products. NBI's core business is to manufacture pharmaceutical products from human plasma, using a process of cold ethanol fractionation. NBI strives to meet the needs of patients and improve their quality of life by providing protein therapies and services within the...
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Guided by its purpose to provide products for patients to alleviate pain and suffering and improve their quality of life, NBI’s vision is to be the leading African manufacturer and supplier of quality therapeutic proteins and diagnostic products.
National Bioproducts Institute NPC has a vacancy for the role of Diagnostic Product Production Analyst . The successful incumbent will be required to :
To use as an individual, his/her academic background, training and experience to perform immunoassay, protein expression and purifications prescribed for the production and QC analysis of saleable monoclonal antibodies, recombinant antigens, and MAT kit and components.
Applications are invited from suitably qualified and experienced candidates.
Minimum Requirements
Essential: BSc in Biochemistry, Microbiology
Preferred: BSc Honours in Biochemistry, Microbiology
2-3 years ELISA experience and
2-3 years recombinant protein expression and purification experience
Duties & Responsibilities
QC testing of MAT ELISA reagents, components and final kits
QC testing of final MAT kit.
Complete documentation for final kit and upload results on SAP
Perform test and method validations according to internal DPP program.
Production and QC testing of recombinant antigens associated with saleable monoclonal antibodies and monoclonal antibodies
Express and purify recombinant proteins to support monoclonal antibody production of saleable antibodies.
When required, assist with purifications of monoclonal antibodies for hybridoma and mAb validation projects
QC testing to validate activity, specificity and coating concentration of produced recombinant antigens.
QC analysis of NBI saleable monoclonal antibodies
Perform QC analysis on purified saleable monoclonal antibodies using sds-page gel electrophoresis and determine the antibody purity by densitometric analysis using gel imaging software.
Provide mAb purity and gel result documentation to Section Head: Antibody Production to complete final release of NBI monoclonal antibodies
Execute activities of the Hybridoma laboratory when required
Perform cell culture and injection duties of the Hybridoma Cell Biologist when required
Culture specific monoclonal antibodies for research and commercial purposes
Interprets and reports results to the Section Head: Antibody Production
Laboratory resourcing and equipment maintenance
Maintain laboratory equipment and cleanliness
Maintain chemical and operational consumable stock levels.
Ensure compliance with ISO13485 standards.
Perform the general housekeeping of the laboratory.
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