Jobs Available at NECSA

Work Description

1. The candidate will develop new synthesis routes for the preparation of bioactive compounds and radio-therapeutics with known biological activities.
2. The candidate will perform synthesis of new linkers and attach them to the bioactive compounds.
3. The candidate will fully characterise the synthesised compounds using various spectrometric and spectroscopic analytical techniques.
4. The candidate will radiolabel the molecules and perform cell uptake and stability studies.
5. The candidate will also be responsible for reporting the completed work in group meetings, assisting with mentoring of Masters and PhD student’s.
6. The candidate will contribute in authoring research reports and publications and presenting at conferences and workshops.
7. The candidate is expected to publish a minimum of two papers (internally or externally peer reviewed) per year.

Requirements

Minimum Requirements:

1. The candidate should hold a PhD in synthetic organic chemistry or medicinal chemistry obtained within the past five years. The candidate should not be older than 45 years at the time of application.
2. Solid knowledge of organic synthesis reactions e.g. carbon-carbon coupling reactions, amide forming reactions, halogenation reactions, protection and deprotection reactions etc.
3. Solid knowledge of various analytical techniques such as thin layer chromatography (TLC), nuclear magnetic resonance (NMR) spectroscopy, high performance liquid chromatography hyphenated with mass spectrometry (HPLC-MS) and Fourier-transform infrared (FT-IR) spectroscopy.
4. Experience in handling radioactivity, molecular modelling and knowledge of some radio-analytical techniques (such as liquid scintillation counter and gamma spectroscopy) and radiation detecting techniques would be an added advantage. 
5. Minimum of one accepted publication in the last five years with additional publications will also be an added advantage. Publications should be in the area of organic chemistry, medicinal chemistry or radiochemistry.
6. Good English communication skills, both oral and written, are a prerequisite.

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Work Description

1. The GMP Formulation Group is seeking outstanding and motivated candidates to apply for a postdoctoral research position that will focus on the GMP compliant production and quality control of potential radiopharmaceuticals (including kit formulations).
2. The researcher will join a dynamic group of scientists involved in translating radiolabelling & quality control processes into GMP compliant methodologies to produce radiopharmaceuticals for evaluation in Phase I-III clinical trials.
3. The candidate must have a good knowledge base regarding the principles of GMP and the regulations/guidelines governing pharmaceutical product manufacturing as well as an understanding of radiopharmaceuticals and radiochemistry.
4. The candidate is expected to contribute to the authoring of general GMP documentation (facility, equipment, processes) and to participate in responsibilities related to the cleanroom facility that is operated and maintained by the Group.
5. The candidate is expected to publish a minimum of two papers (internally or externally peer reviewed) per year and present results obtained at internal group meetings, conferences, colloquiums and workshops.
6. The candidate is also expected to assist in the preparation of funding applications where applicable.

Requirements

Minimum Requirements:

1. The candidate should hold a PhD in Pharmaceutical Sciences, ideally specialized in radiochemistry or radiopharmacy, obtained within the past five years. The candidate should not be older than 45 years at the time of application.
2. Experience in radionuclide handling, radiolabeling techniques, radiopharmaceutical synthesis and quality control will be an advantage.
3. A strong focus on producing research outputs within a team with a minimum of one accepted publication in the last five years with additional publications being an added advantage. Publications should be in the area of Radiochemistry or Pharmaceutical/Radiopharmaceutical Sciences.
4. Strong scientific English language proficiencies is a pre-requisite, particularly written.
5. Effective communication and teamwork capability in a multi-collaborative and interdisciplinary setting.
6. Highly-motivated individual, with strong problem-solving skills and the ability to work independently in accordance to global GLP and GMP standards.