Latest Jobs at ICON plc

• As a Senior Clinical System Lead at ICON, you will play a critical role in the successful delivery of clinical trial systems that support global clinical research programmes. Acting as the lead systems expert across one or more studies, you will oversee the planning, implementation, maitenance, and optimisation of clinical systems, ensuring high-quality, compliant solutions that enable efficient study execution and data collection.
• Working closely with sponsors, study teams, and technology partners, you will provide technical and operational leadership throughout the clinical trial lifecycle while driving continuous improvement and best practices across Clinical Systems.

What You Will Be Doing

• Leading the planning, setup, maintenance, and oversight of clinical systems used within global clinical trials.
• Acting as the clinical systems lead for assigned studies, partnering with internal teams, sponsors, and external vendors to ensure successful delivery.
• Translating protocol and study requirements into effective clinical system solutions that support data collection, review, and reporting activities.
• Providing oversight of system integrations, data flows, and vendor-managed technologies to ensure data quality and operational efficiency.
• Identifying risks, managing issues, and communicating project status to key stakeholders throughout the study lifecycle.
• Supporting study start-up activities, project meetings, system reviews, and customer interactions.
• Reviewing technical documentation, system specifications, and study deliverables to ensure quality and regulatory compliance.
• Leading user acceptance testing and quality review activities for system enhancements and implementations.
• Mentoring junior team members and contributing to process improvement, innovation, and best practice initiatives.
• Supporting business development activities by providing subject matter expertise during proposals and bid defence meetings.

You Will Have

• Bachelor's degree in Computer Science, Information Technology, Life Sciences, Health Informatics, Data Science, or a related discipline.
• Significant experience within Clinical Data Science, Clinical Systems, Clinical Data Management, or Electronic Data Capture (EDC) environments.
• Strong understanding of clinical trial processes, GCP, and regulatory requirements within regulated clinical research environments.
• Experience leading the implementation, management, and optimisation of clinical systems across multiple studies or programmes.
• Knowledge of clinical data platforms, data flows, integrations, and system validation principles.
• Demonstrated project leadership skills with experience managing multiple priorities and stakeholders.

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• We are seeking a Senior Clinical Data Science Programmer to join our Clinical Systems team. In this role, you will serve as a senior technical expert responsible for the design, development and delivery of clinical data solutions that support global clinical trials. Working across study teams, customers and technology partners, you will lead complex programming and system development activities, translating study requirements into high-quality, compliant and scalable clinical data solutions.
• This is an exciting opportunity to work at the intersection of clinical systems, programming and study delivery, supporting the implementation of clinical databases, data review solutions, integrations, analytics and reporting tools that drive decision-making across the clinical trial lifecycle.

What You Will Be Doing:

• Design, configure and maintain clinical data systems and study databases.
• Develop programming solutions supporting data ingestion, validation, extraction and reporting activities.
• Create data review, risk management and analytical outputs that support study oversight.
• Translate business requirements into scalable clinical system solutions.
• Act as a technical lead across study builds and complex system enhancements.
• Support customer engagements and provide subject matter expertise on clinical data technologies.
• Ensure high-quality delivery through adherence to SDLC, validation and quality control processes.
• Mentor junior programmers and contribute to continuous improvement initiatives.

You Will have/be:

• Bachelor's degree in Computer Science, Data Science, Life Sciences or a related discipline.
• Significant experience within Clinical Data Science, Clinical Systems or Clinical Programming.
• Strong experience working with clinical databases, data integration, analytics or data review platforms.
• Experience using programming languages such as R, Python, SQL or equivalent technologies.
• Understanding of clinical trial processes, data standards and regulatory expectations.
• Experience working directly with customers and cross-functional stakeholders.
• Excellent problem-solving, communication and project coordination skills.

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• Firecrest Clinical is part of the ICON plc Group and produces highly visual and engaging products for the Clinical Trial Industry. Firecrest products help improve Site performance by delivering innovative and effective training to sites while complying with Industry Standards. As an organisation responsible for the development of clinical training for medical staff, the Clinical Trial Advisor role is critical to the delivery of accurate and high quality training products to our clients.

What you will be doing 

• Uses clinical research experience, accrued from previous clinical research roles, to assist colleagues in the production of accurate and engaging components for our stakeholders.
• Works actively, independently or with the team (depending on the task), to create the high quality digital solutions in line with the sponsor's needs and expectations, and within sponsor delivery timelines.
• Advises and supports the production team (Instructional Designer, Graphic Designer, Product Testing Analysts) on clinical trial related matters, across therapeutic areas.
• Ensures technical accuracy of the products/solutions at each stage of the product development, while ensuring the clinical content adds maximum value for end users (Sponsors, Site Staff, Investigators, and Patients).
• Conducts comprehensive review of study documentation provided by the sponsor
• Attends sponsor meetings and assists Project Manager (PM) as required to support product development
• Communicates/escalates protocol-related queries to the Project Manager (PM)/In Team Lead (ITL).
• Maintains a working knowledge of ICH/GCP Guidelines or other applicable guidance, relevant regulations, and company SOPs/processes; completes assigned training as required.
• Assumes additional responsibilities as directed by CTSME Supervisor and/or other management.
• Identifies operational efficiencies and process improvements, contributing to an environment of continuous learning and improvement.
• Depending on level of experience, assists in training and mentoring of less experienced CT SMEs.
• Ensure the maintenance of a high personal level of knowledge concerning current regulation and changes within the clinical research industry by means of internal support and individual learning.

Your profile 

• B.Sc. (Hons) in life science or equivalent.
• Minimum 2-3 years' experience as a CRA/site coordinator/study nurse within the clinical research industry
• Experience across different trial phases and therapeutic areas
• Excellent practical knowledge and understanding of the complexity of clinical trials and experience with different clinical trial systems/vendors
• Excellent analytical skills and attention to detail
• Ability to work independently as well as part of the project team, depending on the solution requirements
• Ability to produce accurate work within tight deadlines
• Knowledge of ICH GCP guidelines and experience in reviewing study-related documentation
• Excellent written and verbal communication in English

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• As a Clinical Data Risk Analyst (Speaking Mandarin) at ICON, you will identify and mitigating risks associated with clinical trial data. You will contribute to the overall success of our clinical programs by employing risk assessment methodologies to ensure data integrity and compliance with regulatory standards.

What You Will Do:

• Your role will involve delivering clinical research work to a high standard, working closely with your team and stakeholders.

Key responsibilities include:

• Conducting risk assessments on clinical trial data to identify potential issues and recommend mitigation strategies.
• Collaborating with cross-functional teams to develop and implement risk management plans and protocols.
• Monitoring data quality and integrity throughout the trial process, reporting findings to stakeholders.
• Utilizing statistical analysis and visualization tools to communicate risk-related insights effectively.
• Supporting the preparation of risk management documentation for regulatory submissions and audits.

Your Profile:

• You will bring relevant clinical research experience, along with the following qualifications and skills.

Required qualifications and experience:

• Degree in statistics, life sciences, or a related field.
• Proficiency in English and Mandarin mandatory.
• Experience in clinical data analysis or risk management within a clinical research environment.
• Strong analytical skills with proficiency in statistical software and risk assessment methodologies.
• Attention to detail and a proactive approach to identifying and addressing data risks.
• Effective communication skills, with the ability to collaborate across diverse teams and convey complex information clearly.

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• As a SCRA  or CRA at ICON, you will design and analyse clinical trials, interpreting complex medical data, and contribute to the advancement of innovative treatments and therapies.

What You Will Do:

• You will contribute to clinical trial monitoring activities, taking responsibility for your deliverables and working collaboratively.

Key responsibilities include:

• Conducting site qualification, initiation, monitoring, and close-out visits for clinical trials.
• Ensuring protocol compliance, data integrity, and patient safety throughout the trial process.
• Collaborating with investigators and site staff to facilitate smooth study conduct.
• Performing data review and resolution of queries to maintain high-quality clinical data.
• Contributing to the preparation and review of study documentation, including protocols and clinical study reports

Your Profile:

• You will bring relevant clinical trial monitoring experience, along with the following qualifications and skills.

Required qualifications and experience:

• Bachelor's degree in a scientific or healthcare-related field.
• Minimum of 3 years of independent monitoring experience as a Clinical Research Associate for CRA II level role.
• Minimum of 5 years independent monitoring experience as a Clinical Research Associate for SCRA level role.
• In-depth knowledge of clinical trial processes, regulations, and ICH-GCP guidelines.
• Strong organizational and communication skills, with attention to detail.
• Ability to work independently and collaboratively in a fast-paced environment.
• Willingness to travel as required (approximately 60%)

Based in and around Johannesburg

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• We are currently seeking a Clinical Trial Manager to join our diverse and dynamic team at ICON Plc - this position will sit within ICON Biotech. In this critical role, you will be responsible for overseeing the planning, execution, and successful completion of clinical trials, ensuring adherence to timelines, budgets, and regulatory guidelines. As a leader in our research department, you will collaborate with cross-functional teams, manage site relationships, and provide strategic guidance to drive the successful delivery of clinical trial outcomes.

What you will be doing 

• Plan and manage all aspects of clinical trials, ensuring adherence to timelines, budget, and quality standards.
• Collaborate with cross-functional teams to establish and implement clinical trial protocols and procedures.
• Build and manage strong relationships with trial investigators and stakeholders.
• Ensure all trials are conducted in compliance with local, national, and international regulations and ethical guidelines.
• Problem-solve and make critical decisions regarding trial design, vendor selection, and risk management.

Your Profile

• University degree in medicine, science, or equivalent combination of education & experience
• Multi country Clinical Trial Management expertise
• Demonstrated ability to drive the clinical deliverables of a study
• Subject matter expertise in the designated therapeutic area
• Prior monitoring experience is preferred
• Ability to travel up to 20%

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• As a Senior Biostatistician I at ICON, you will design and analyse clinical trials, interpreting complex medical data, and contribute to the advancement of innovative treatments and therapies.

What You Will Do:

• You will lead on biostatistics tasks requiring technical depth, with a focus on quality and continuous improvement.

Key responsibilities include:

• Serves as lead biostatistician for simple to complex clinical studies.
• 5 years work experience required.
• Biomarker work experience mandatory.
• Develops statistical analysis plans and reporting specifications.
• Responsible for statistical aspects of CRF design and edit specifications.
• Performs statistical analyses and interprets results for simple to complex clinical studies.
• Reviews simple to complex randomization specifications and dummy randomization schemes.
• Participates in bid defense meetings.

Your Profile:

• You will have a strong foundation in biostatistics, with the experience to work independently and guide others.

Required qualifications and experience:

• Master's degree or Ph.D in Biostatistics, Statistics, or a related field with 5 or more years of biostatistical experience.
• Strong knowledge of multiple statistical and therapeutic areas, the drug development process, and statistical programming practices and procedures.
• Excellent problem-solving skills and attention to detail.
• Effective communication skills to collaborate with multidisciplinary teams.