Lead Cloud Operations Database Architect at Signant Health

Where do you fit in?

• We are seeking a highly experienced Lead Cloud Operations Database Architect to design, implement, and govern enterprise data architecture supporting regulated clinical research systems. This role owns all database-related aspects across Microsoft Azure and AWS cloud environments, ensuring performance, security, scalability, and compliance with GxP, FDA 21 CFR Part 11, and ICH-GCP regulations.
• The ideal candidate brings deep technical expertise across MS SQL, Azure SQL, AWS RDS, and Cloud SQL in high-volume production environments, paired with strong leadership in data governance, architecture design, and lifecycle management for mission-critical clinical trial platforms.

Key Responsibilities

Architecture & Design

• Design and maintain enterprise-scale data architectures supporting clinical trial systems
• Ensure high availability, scalability, resilience, and security across Azure and AWS environments

Database Administration & Operations

• Own database setup, configuration, backup/recovery, replication, and performance tuning
• Support MS SQL Server, Azure SQL, AWS RDS, and Cloud SQL in production environments

Regulatory Compliance

• Establish and enforce database procedures aligned with GxP and FDA regulations
• Partner with QA/Compliance teams to support audits, validation, and inspections

Security & Data Integrity

• Implement access controls, encryption, monitoring, and logging to protect sensitive clinical and patient data

Automation & DevOps Integration

• Automate provisioning, patching, and schema deployments using CI/CD and IaC
• Work with tools such as Terraform, OpenTofu, ARM templates, and AWS CloudFormation

Cross-Functional Leadership

• Collaborate with Engineering, Project Management, and Compliance teams to align enterprise data strategies

Monitoring & Optimization

• Implement proactive alerting, capacity planning, and performance optimization

Documentation & Standards

• Maintain architecture diagrams, SOPs, and technical documentation to support audits and validation

You’ll need to bring

• Bachelor’s degree in Computer Science, Information Systems, or related field (Master’s preferred)
• 10+ years of experience in database architecture/administration
• 5+ years of cloud experience across Azure and AWS
• Deep expertise in MS SQL Server, Azure SQL Database, and AWS RDS
• Proven experience supporting regulated (GxP / FDA) environments
• Strong understanding of data security, governance, and compliance in life sciences or healthcare
• Hands-on experience with IaC, monitoring platforms (CloudWatch, Azure Monitor), and automation scripting (PowerShell, Python, or Bash)
• Strong communication skills and the ability to partner with cross-functional technical and clinical teams

Nice to have

• Experience integrating with clinical data systems (CDMS, EDC, LIMS)
• Familiarity with Snowflake, data lakes, and ETL/ELT pipelines
• Cloud certifications such as Azure Database Administrator or AWS Database Specialty

Key Competencies

• Strategic, system-level thinking
• Strong data integrity and compliance mindset
• Technical leadership and mentoring capability
• Analytical problem-solving
• Effective cross-team communication