Senior Site Activation Manager (SAM) Sponsor-Dedicated/ Remote - US Based at Syneos Health Clinical Solutions

Why This Role

• This is a high-visibility opportunity for outstanding Site Activation Managers ready to step into a more strategic, sponsor-facing role within an FSP model. You’ll lead global site activation efforts while helping shape processes in a fast-evolving environment.

What You’ll Own
End-to-End SSU Leadership

• Drive global site start-up strategy and execution from site identification through activation and lifecycle maintenance
• Own SSU timelines, forecasts, and delivery against contracted milestones
• Identify risks early (regulatory, enrollment, timelines) and implement mitigation plans

Operational Oversight

• Lead all start-up deliverables, including:
• Site identification and feasibility
• Regulatory submissions and lifecycle maintenance (amendments, HA/EC communications, licenses)
• CTA and investigator budget negotiation/execution
• Essential document collection and TMF readiness
• Ensure delivery aligns with SOPs, sponsor expectations, and quality standards

Sponsor & Cross-Functional Engagement

• Act as a key interface with sponsor stakeholders, presenting strategy, risks, and status
• Partner across Clinical Ops, PM, Contracts, Data Management, Medical Writing, and SSU Country teams
• Collaborate within a team-first, highly accountable FSP environment

Financial & Scope Accountability

• Review SSU budgets vs. milestones and support profitability targets
• Track and manage out-of-scope activities in partnership with PM/SSU leadership

Regulatory Leadership

• Oversee preparation of core submission documents and amendment dossiers
• Conduct Regulatory Impact Assessments and communicate risks
• Support development of SIS/ICF documents and country-specific submissions

Process & Build Mindset

• Contribute to process creation and refinement as the team scales
• Operate effectively in a setting where execution and process development happen in parallel

Required Experience

• Minimum 3 years prior experience as a Site Activation Manager (SAM).
• Minimum of 2 years' experience in Managing large scale, US-based Site Activation with high success.
• Strong track record delivering SSU activities across Phase II–IV trials
• Solid understanding of ICH-GCP, regulatory pathways, and start-up processes
• Demonstrated ability to manage multiple studies and competing priorities
• Strong communication, stakeholder management, and problem-solving skills

Highly Preferred

• FSP (Functional Service Provider) experience
• Prior Global SAM responsibility (regional experience considered with strong performance, if US based sites.)
• Experience integrating Syneos and sponsor systems
• Proven ability to operate in ambiguity and help build processes while delivering
• Track record of high performance and readiness for increased scope/visibility